SS02 - Outcomes of Early Trans-carotid Artery Revascularization versus Carotid Endarterectomy After Acute Neurologic Events

Objectives: Carotid revascularization within 14 days of a neurologic event is recommended by society guidelines. Transcarotid artery revascularization (TCAR) carries the lowest overall stroke rate for any carotid artery stenting technique; however, outcomes of TCAR within 14 days of a neurologic event have not been studied or directly compared to carotid endarterectomy (CEA).

Methods: We compared in-hospital outcomes of symptomatic patients undergoing TCAR and CEA within 14 days of stroke or transient ischemic attack (TIA) from January 2016 to February 2020 using the Society for Vascular Surgery Vascular Quality Initiative (VQI) carotid artery stenting and CEA databases. Propensity score matching was used to adjust for patient risk factors. The primary outcome was a composite of postoperative ipsilateral stroke, death, and myocardial infarction (MI).

Results: A total of 1,281 symptomatic patients underwent TCAR and 13,429 patients underwent CEA within 14 days of a neurologic event. After 1:1 propensity matching, 728 matched pairs were included for analysis. The primary composite outcome of stroke, death, or MI was more frequent in the TCAR group (4.7% vs. 2.6%, p= 0.04). This was driven by a higher rate of post-operative ipsilateral stroke in the TCAR group (3.8% vs. 1.8%, p=0.005). There was no difference between TCAR and CEA in terms of death (0.7% vs. 0.8%, p= 0.8) or MI (0.8% vs. 1%, p= 0.7). Although TCAR procedures were shorter (69 minutes IQR 53-85 vs. 120 minutes IQR 93-150, p< 0.001) and post procedure length of stay was similar (2 days, p= 0.3) compared to CEA, TCAR patients were more likely to be discharged to a facility other than home (26% vs. 18.9%, p< 0.01). Performing TCAR within 48 hours of a stroke was an independent predictor of post-operative stoke or TIA (OR 5.4 95% CI 1.8-16).

Conclusions: TCAR within 14 days of a neurologic event results in higher ipsilateral post-operative stroke rates when compared to CEA, especially when performed within 48 hours.